Amyloid β-Protein Aβ1-42 Diagnostic Lab Reagents In POClia

Alzheimer's Disease (amyloid β-protein, Aβ1-42) in POClia
 
β-amyloid (amyloid β-protein, Aβ) has a molecular weight of about 4kDa, is hydrolyzed by β-amyloid precursor protein (APP), is secreted by cells, and has a strong ability to accumulate after cell matrix precipitation. neurotoxic effects.
Amyloid-β (Aβ) is a polypeptide containing 39-43 amino acids produced by the proteolysis of amyloid precursor protein (APP) by β- and γ-secretase. It can be produced by a variety of cells and circulate in the blood, cerebrospinal fluid and brain interstitial fluid, most of which are combined with chaperone molecules, and a few exist in free state. The most common isoforms of Aβ in humans are Aβ1-40 and Aβ1-42. In human cerebrospinal fluid and blood, the levels of Aβ1-40 were 10 times and 10 times higher than that of Aβ1-42, respectively. 5 times, Aβ1-42 are more toxic and more likely to aggregate, thus forming the core of Aβ precipitation and triggering neurotoxicity.
 
 
EXPLANATION OF THE TEST
 
The deposition of Aβ is not only related to neuronal degeneration, but also activates a series of pathological events, including activation of astrocytes and microglia, disruption of the blood-brain barrier, and changes in microcirculation. It is the main cause of neuronal degeneration and death around senile plaques in AD patients' brains.
 
 

 
 


 
 
 
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